Green TiO2 as Nanocarriers for Targeting Cervical Cancer Cell Lines
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Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytototoxicity in cancer cells. Drug delivery systems are designed to achieve drug therapeutic index and enhance the efficacy of controlled drug release targeting with specificity and selectivity by successful delivery of therapeutic agents at the desired sites without affecting the non-diseased neighbouring cells or tissues. In this work, nano-titanium dioxide, as anatase phase, was obtained by the sol-gel method with a cleaner technology a bio-extract obtained from the plant Artemisia pallens containing poly alcohols- used as a solvent, the structural, optical, particle size and the morphological properties of TiO2 nanoparticles were analyzed using x-ray diffraction data, scanning electron microscope. The green TiO2 nanoparticles had a bandgap of 3.2 eV. The fourier transformer infra red spectroscopy (FT-IR) shows a single band attributed to TiO2 using the simple aqueous based organic solvent free approach is further used as nano carriers for drug delivery system. Also we have developed and demonstrated a bio-based titanium dioxide that can be loaded with anticancer drug and selectively deliver it to cancer cells with high specificity by achieving the effective cervical cancer cell death without inducing specific toxicity. The study showed that the DOX loaded TiO2 nanocrystals has promising applications in delivery of anticancer drugs.
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About the Book
Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytototoxicity in cancer cells. Drug delivery systems are designed to achieve drug therapeutic index and enhance the efficacy of controlled drug release targeting with specificity and selectivity by successful delivery of therapeutic agents at the desired sites without affecting the non-diseased neighbouring cells or tissues. In this work, nano-titanium dioxide, as anatase phase, was obtained by the sol-gel method with a cleaner technology a bio-extract obtained from the plant Artemisia pallens containing poly alcohols- used as a solvent, the structural, optical, particle size and the morphological properties of TiO2 nanoparticles were analyzed using x-ray diffraction data, scanning electron microscope. The green TiO2 nanoparticles had a bandgap of 3.2 eV. The fourier transformer infra red spectroscopy (FT-IR) shows a single band attributed to TiO2 using the simple aqueous based organic solvent free approach is further used as nano carriers for drug delivery system. Also we have developed and demonstrated a bio-based titanium dioxide that can be loaded with anticancer drug and selectively deliver it to cancer cells with high specificity by achieving the effective cervical cancer cell death without inducing specific toxicity. The study showed that the DOX loaded TiO2 nanocrystals has promising applications in delivery of anticancer drugs.
About the Author
Dr. S. Senthilkumaar, presently working as Assistant Professor – Senior Grade in the Department of Chemistry, PSG College of Technology, Coimbatore, Tamil Nadu since 2001. He has 21 years of total teaching, research and industrial experience. He was the recipient of “Young Scientist Award” offered by the Tamil Nadu State Council for Science and Technology in the year 2003. His areas of research interest are Nano Catalysts for Organic reactions, non-toxic agricultural biomass for Environmental Remediation, Environmental Photochemistry, Ceramics, composite materials, inorganic ion-exchangers for detoxicification of ground water and Nano Carriers for drug delivery for malignant cells. To his credit, he has published more than 50 research articles in an international peer-reviewed journals published from ACS, IOP, Elsevier, etc. He is honored by Editors of several journals published from Elsevier, John Wiley, ACS by appointing him as a regular reviewer for their journals, as a token of his contribution. He has very good citation index. He has produced 7 PhD students under his guidance as on 2016. Most of his full-time research students are the recipient of National Doctoral Research Fellowship offered by AICTE, New Delhi. He delivered key note address in several national and international conferences and also served as a session chairman. He is also serving as a Board of Studies member in many of the autonomous Engineering College under Anna University and Arts and Science College under Bharathiar University.